Doucouré Souleymane, Mouchet François, Cornélie Sylvie, DeHecq J. S., Rutee A. H., Roca Y., Walter Annie, Hervé Jean-Pierre, Missé Dorothée, Favier F., Gasque P., Remoué Franck. (2012). Evaluation of the human igg antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. Plos Neglected Tropical Diseases, 6 (2), p. e1487. ISSN 1935-2727.
Titre du document
Evaluation of the human igg antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites
Année de publication
2012
Auteurs
Doucouré Souleymane, Mouchet François, Cornélie Sylvie, DeHecq J. S., Rutee A. H., Roca Y., Walter Annie, Hervé Jean-Pierre, Missé Dorothée, Favier F., Gasque P., Remoué Franck
Source
Plos Neglected Tropical Diseases, 2012,
6 (2), p. e1487 ISSN 1935-2727
Background: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. Methodology/Principal Findings: We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island. The percentage of immune responders (88%) and levels of anti-SGE IgG Abs were high in exposed individuals. At an individual level, our results indicate heterogeneity of the exposure to Aedes albopictus bites. In addition, low-level immune cross-reactivity between Aedes albopictus and Aedes aegypti SGEs was observed, mainly in the highest responders. Conclusion/Significance: Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of Aedes albopictus control strategies.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010055723]
Identifiant IRD
fdi:010055723
