Doucouré Souleymane auteur aut IRD Mouchet François auteur aut IRD Cornélie Sylvie auteur aut IRD DeHecq J. S. auteur aut IRD Rutee A. H. auteur aut IRD Roca Y. auteur aut IRD Walter Annie auteur aut IRD Hervé Jean-Pierre auteur aut IRD Missé Dorothée auteur aut IRD Favier F. auteur aut IRD Gasque P. auteur aut IRD Remoué Franck auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. Methodology/Principal Findings: We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island. The percentage of immune responders (88%) and levels of anti-SGE IgG Abs were high in exposed individuals. At an individual level, our results indicate heterogeneity of the exposure to Aedes albopictus bites. In addition, low-level immune cross-reactivity between Aedes albopictus and Aedes aegypti SGEs was observed, mainly in the highest responders. Conclusion/Significance: Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of Aedes albopictus control strategies. specialized 052 6 2 e1487 2012 1935-2727 https://www.documentation.ird.fr/hor/fdi:010055723 10.1371/journal.pntd.0001487 1935-2727 [F B010055723] https://www.documentation.ird.fr/hor/fdi:010055723 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010055723.pdf IRD - Base Horizon / Pleins textes 2012-05-04 2017-10-03 fdi:010055723 fre