@article{fdi:010055723,
  title = {{E}valuation of the human igg antibody response to {A}edes albopictus saliva as a new specific biomarker of exposure to vector bites},
  author = {{D}oucour{\'e}, {S}ouleymane and {M}ouchet, {F}ran{\c{c}}ois and {C}orn{\'e}lie, {S}ylvie and {D}e{H}ecq, {J}. {S}. and {R}utee, {A}. {H}. and {R}oca, {Y}. and {W}alter, {A}nnie and {H}erv{\'e}, {J}ean-{P}ierre and {M}iss{\'e}, {D}oroth{\'e}e and {F}avier, {F}. and {G}asque, {P}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he spread of {A}edes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. {H}uman antibody ({A}b) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. {M}ethodology/{P}rincipal {F}indings: {W}e used {ELISA} tests to evaluate specific immunoglobulin {G} ({I}g{G}) responses to salivary gland extracts ({SGE}) in adults exposed to {A}edes albopictus in {R}eunion {I}sland. {T}he percentage of immune responders (88%) and levels of anti-{SGE} {I}g{G} {A}bs were high in exposed individuals. {A}t an individual level, our results indicate heterogeneity of the exposure to {A}edes albopictus bites. {I}n addition, low-level immune cross-reactivity between {A}edes albopictus and {A}edes aegypti {SGE}s was observed, mainly in the highest responders. {C}onclusion/{S}ignificance: {A}b responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to {A}edes albopictus bites. {C}ombined with entomological and epidemiological methods, a "salivary" biomarker of exposure to {A}edes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of {A}edes albopictus control strategies.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {6},
  numero = {2},
  pages = {e1487},
  ISSN = {1935-2727},
  year = {2012},
  DOI = {10.1371/journal.pntd.0001487},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055723},
}