Cachet N., Ho-A-Kwie F., Rivaud M., Houël E., Deharo Eric, Bourdy Geneviève, Jullian Valérie. (2012). Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae). Phytochemistry Letters, 5 (1), p. 162-164. ISSN 1874-3900.
Titre du document
Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)
Cachet N., Ho-A-Kwie F., Rivaud M., Houël E., Deharo Eric, Bourdy Geneviève, Jullian Valérie
Source
Phytochemistry Letters, 2012,
5 (1), p. 162-164 ISSN 1874-3900
A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guiana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC50 = 8 mu M), and a similar low activity on human cancerous cells line (IC50 = 7 mu M on MCF-7 cells line).
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
