%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Cachet, N.
%A Ho-A-Kwie, F.
%A Rivaud, M.
%A Houël, E.
%A Deharo, Eric
%A Bourdy, Geneviève
%A Jullian, Valérie
%T Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)
%D 2012
%L fdi:010054411
%G ENG
%J Phytochemistry Letters
%@ 1874-3900
%K Quassia amara ; Simaroubaceae ; Quassinoids ; Malaria ; P. falciparum
%K GUYANE FRANCAISE
%M ISI:000300395900035
%N 1
%P 162-164
%R 10.1016/j.phytol.2011.12.001
%U https://www.documentation.ird.fr/hor/fdi:010054411
%> https://www.documentation.ird.fr/intranet/publi/2012/03/010054411.pdf
%V 5
%W Horizon (IRD)
%X A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guiana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC50 = 8 mu M), and a similar low activity on human cancerous cells line (IC50 = 7 mu M on MCF-7 cells line).
%$ 076 ; 052