Wurtz N., Lekweiry K. M., Bogreau H., Pradines B., Rogier C., Ould Mohamed Salem Boukhary A.S., Hafid J. E., Ould Ahmedou Salem M.S., Trape Jean-François, Basco Leonardo, Briolant S. (2011). Vivax malaria in Mauritania includes infection of a Duffy-negative individual. Malaria Journal, 10, 336 [8 p.]. ISSN 1475-2875.
Titre du document
Vivax malaria in Mauritania includes infection of a Duffy-negative individual
Année de publication
2011
Auteurs
Wurtz N., Lekweiry K. M., Bogreau H., Pradines B., Rogier C., Ould Mohamed Salem Boukhary A.S., Hafid J. E., Ould Ahmedou Salem M.S., Trape Jean-François, Basco Leonardo, Briolant S.
Source
Malaria Journal, 2011,
10, 336 [8 p.] ISSN 1475-2875
Background: Duffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania. Methods: Plasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables. Results: In the Moorish population, a high frequency of the FYBES/FYBES genotype was observed in uninfected individuals (27.8%), whereas no P. vivax-infected patient had this genotype. This was followed by a high level of FYA/FYB, FYB/FYB, FYB/FYBES and FYA/FYBES genotype frequencies, both in the P. vivax-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the FYBES/FYBES genotype was found in uninfected patients, whereas the FYA/FYBES genotype was observed in two P. vivax-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the FYBES/FYBES genotype and was infected by P. vivax. Conclusions: This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent P. vivax invasion of human red blood cells.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010054220]
Identifiant IRD
fdi:010054220
