%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Wurtz, N.
%A Lekweiry, K. M.
%A Bogreau, H.
%A Pradines, B.
%A Rogier, C.
%A Ould Mohamed Salem Boukhary, A.S.
%A Hafid, J. E.
%A Ould Ahmedou Salem, M.S.
%A Trape, Jean-François
%A Basco, Leonardo
%A Briolant, S.
%T Vivax malaria in Mauritania includes infection of a Duffy-negative individual
%D 2011
%L fdi:010054220
%G ENG
%J Malaria Journal
%@ 1475-2875
%K Plasmodium vivax ; Duffy blood group ; Mauritania ; polymorphism ; malaria
%M ISI:000297548700001
%P 336 [8 ]
%R 10.1186/1475-2875-10-336
%U https://www.documentation.ird.fr/hor/fdi:010054220
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-02/010054220.pdf
%V 10
%W Horizon (IRD)
%X Background: Duffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania. Methods: Plasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables. Results: In the Moorish population, a high frequency of the FYBES/FYBES genotype was observed in uninfected individuals (27.8%), whereas no P. vivax-infected patient had this genotype. This was followed by a high level of FYA/FYB, FYB/FYB, FYB/FYBES and FYA/FYBES genotype frequencies, both in the P. vivax-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the FYBES/FYBES genotype was found in uninfected patients, whereas the FYA/FYBES genotype was observed in two P. vivax-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the FYBES/FYBES genotype and was infected by P. vivax. Conclusions: This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent P. vivax invasion of human red blood cells.
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