Arvold N. D., Ngo Giang Huong Nicole, McIntosh K., Suraseranivong V., Warachit B., Piyaworawong S., Changchit T., Lallemant Marc, Jourdain Gonzague. (2007). Maternal HIV-1 DNA load and mother-to-child transmission. Aids Patient Care and Stds, 21 (9), p. 638-643. ISSN 1087-2914.
Titre du document
Maternal HIV-1 DNA load and mother-to-child transmission
Arvold N. D., Ngo Giang Huong Nicole, McIntosh K., Suraseranivong V., Warachit B., Piyaworawong S., Changchit T., Lallemant Marc, Jourdain Gonzague
Source
Aids Patient Care and Stds, 2007,
21 (9), p. 638-643 ISSN 1087-2914
While many factors contribute to mother-to-child transmission (MTCT) of HIV-1, maternal plasma HIV-1 RNA viral load (RNA-VL) has been consistently found as the main risk factor, including when antiretroviral prophylaxis was used to prevent MTCT. However the predictive value of RNA-VL is poor. A recent study of HIV-1-positive pregnant women who did not receive antiretroviral prophylaxis reported an association between HIV-1 DNA viral load (DNA-VL) and MTCT that was stronger than the association between RNA-VL and MTCT. We sought to determine if HIV-1 DNA-VL was independently associated with MTCT of HIV in a population of women who received zidovudine prophylaxis during pregnancy and whose infants received zidovudine after birth. Patients were 33 non-breastfeeding transmitting (TR) and 33 nontransmitting mothers (NTR) from Perinatal HIV Prevention Trial (PHPT-1), a multicenter clinical trial conducted in Thailand comparing zidovudine prophylaxis durations to prevent MTCT. TR and NTR mothers were matched according to baseline RNA-VL. Maternal peripheral blood mononuclear cell (PBMC)-associated HIV-1 DNA was extracted from whole blood, and DNA-VL was established by quantitative real-time polymerase chain reaction. We found that TR had a significantly higher cell-associated HIV-1 DNA viral load than did NTR. Median TR DNA-VL was 2.54 log(10) copies per microgram PBMC DNA, while it was 2.28 log(10) copies per microgram PBMC DNA in NTR (Wilcoxon p = 0.02). In summary, HIV-1 DNA viral load was associated with MTCT in a population of women who received antiretroviral prophylaxis during pregnancy, independently from RNA viral load.
