@article{fdi:010052476,
  title = {{M}aternal {HIV}-1 {DNA} load and mother-to-child transmission},
  author = {{A}rvold, {N}. {D}. and {N}go {G}iang {H}uong, {N}icole and {M}c{I}ntosh, {K}. and {S}uraseranivong, {V}. and {W}arachit, {B}. and {P}iyaworawong, {S}. and {C}hangchit, {T}. and {L}allemant, {M}arc and {J}ourdain, {G}onzague},
  editor = {},
  language = {{ENG}},
  abstract = {{W}hile many factors contribute to mother-to-child transmission ({MTCT}) of {HIV}-1, maternal plasma {HIV}-1 {RNA} viral load ({RNA}-{VL}) has been consistently found as the main risk factor, including when antiretroviral prophylaxis was used to prevent {MTCT}. {H}owever the predictive value of {RNA}-{VL} is poor. {A} recent study of {HIV}-1-positive pregnant women who did not receive antiretroviral prophylaxis reported an association between {HIV}-1 {DNA} viral load ({DNA}-{VL}) and {MTCT} that was stronger than the association between {RNA}-{VL} and {MTCT}. {W}e sought to determine if {HIV}-1 {DNA}-{VL} was independently associated with {MTCT} of {HIV} in a population of women who received zidovudine prophylaxis during pregnancy and whose infants received zidovudine after birth. {P}atients were 33 non-breastfeeding transmitting ({TR}) and 33 nontransmitting mothers ({NTR}) from {P}erinatal {HIV} {P}revention {T}rial ({PHPT}-1), a multicenter clinical trial conducted in {T}hailand comparing zidovudine prophylaxis durations to prevent {MTCT}. {TR} and {NTR} mothers were matched according to baseline {RNA}-{VL}. {M}aternal peripheral blood mononuclear cell ({PBMC})-associated {HIV}-1 {DNA} was extracted from whole blood, and {DNA}-{VL} was established by quantitative real-time polymerase chain reaction. {W}e found that {TR} had a significantly higher cell-associated {HIV}-1 {DNA} viral load than did {NTR}. {M}edian {TR} {DNA}-{VL} was 2.54 log(10) copies per microgram {PBMC} {DNA}, while it was 2.28 log(10) copies per microgram {PBMC} {DNA} in {NTR} ({W}ilcoxon p = 0.02). {I}n summary, {HIV}-1 {DNA} viral load was associated with {MTCT} in a population of women who received antiretroviral prophylaxis during pregnancy, independently from {RNA} viral load.},
  keywords = {},
  booktitle = {},
  journal = {{A}ids {P}atient {C}are and {S}tds},
  volume = {21},
  numero = {9},
  pages = {638--643},
  ISSN = {1087-2914},
  year = {2007},
  DOI = {10.1089/apc.2006.0169},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052476},
}