Human antibody response to Anopheles gambiae saliva : an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control

2010

Article référencé dans le Web of Science WOS:000279366300024

Dramé Papa Maktar, Poinsignon Anne, Besnard P., Le Mire J., Dos-Santos M. A., Sow C. S., Cornélie Sylvie, Foumane V., Toto J. C., Sembène M., Boulanger Denis, Simondon François, Fortes F., Carnevale Pierre, Remoué Franck

American Journal of Tropical Medicine and Hygiene, 2010, 83 (1), p. 115-121 ISSN 0002-9637

For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.

Entomologie médicale / Parasitologie / Virologie [052]

ANGOLA

Fonds IRD [F B010049620]

fdi:010049620