%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Dramé, Papa Maktar
%A Poinsignon, Anne
%A Besnard, P.
%A Le Mire, J.
%A Dos-Santos, M. A.
%A Sow, C. S.
%A Cornélie, Sylvie
%A Foumane, V.
%A Toto, J. C.
%A Sembène, M.
%A Boulanger, Denis
%A Simondon, François
%A Fortes, F.
%A Carnevale, Pierre
%A Remoué, Franck
%T Human antibody response to Anopheles gambiae saliva : an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control
%D 2010
%L fdi:010049620
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K ANGOLA
%M ISI:000279366300024
%N 1
%P 115-121
%R 10.4269/ajtmh.2010.09-0684
%U https://www.documentation.ird.fr/hor/fdi:010049620
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010049620.pdf
%V 83
%W Horizon (IRD)
%X For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.
%$ 052