Niama F.R., Vidal Nicole, Bazepeo S.E., Mpoudi E., Toure-Kane C., Parra H.J., Delaporte Eric, Peeters Martine. (2009). CRF45_AKU, a circulating recombinant from Central Africa, is probably the common ancestor of HIV type 1 MAL and HIV type 1 NOGIL. Aids Research and Human Retroviruses, 25 (12), p. 1345-1353. ISSN 0889-2229.
Titre du document
CRF45_AKU, a circulating recombinant from Central Africa, is probably the common ancestor of HIV type 1 MAL and HIV type 1 NOGIL
Année de publication
2009
Auteurs
Niama F.R., Vidal Nicole, Bazepeo S.E., Mpoudi E., Toure-Kane C., Parra H.J., Delaporte Eric, Peeters Martine
Source
Aids Research and Human Retroviruses, 2009,
25 (12), p. 1345-1353 ISSN 0889-2229
In this study, we characterized four HIV-1 strains from Cameroon, Gabon, and the Democratic Republic of Congo (DRC), collected during independent serosurveys, and previously found to cluster in the pol gene with HIV-1MAL and HIV-1 NOGIL3, two complex recombinant viruses reported in the early HIV epidemic, and with the recombinant strain 04FR. AUK recently described in France. The four newly sequenced viruses shared the same structure as 04FR. AUK, involving alternating fragments of subtype A, K, and unclassified (U) fragments, representing a new CRF called CRF45_AKU. Some of the unclassified fragments were related to unclassified regions described in either CRF04 or CRF09 strains. Careful reanalysis of HIV-1 MAL and HIV-1 NOGIL3 demonstrated that these strains were related exclusively to CRF45_AKU and either two subtype D fragments for HIV-1 MAL or one subtype H segment for HIV-1 NOGIL3. Following extensive blast searches, related gag, pol, and env sequences were observed in Central and West Africa (Senegal, Mali), as well as in Europe (France, Spain, Italy, Cyprus), Argentina, and China.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CAMEROUN ; GABON ; REPUBLIQUE DEMOCRATIQUE DU CONGO
Localisation
Fonds IRD [F B010048445]
Identifiant IRD
fdi:010048445
