Niama F.R. auteur aut IRD Vidal Nicole auteur aut IRD Bazepeo S.E. auteur aut IRD Mpoudi E. auteur aut IRD Toure-Kane C. auteur aut IRD Parra H.J. auteur aut IRD Delaporte Eric auteur aut IRD Peeters Martine auteur aut IRD text journalArticle eng text/pdf born digital access In this study, we characterized four HIV-1 strains from Cameroon, Gabon, and the Democratic Republic of Congo (DRC), collected during independent serosurveys, and previously found to cluster in the pol gene with HIV-1MAL and HIV-1 NOGIL3, two complex recombinant viruses reported in the early HIV epidemic, and with the recombinant strain 04FR. AUK recently described in France. The four newly sequenced viruses shared the same structure as 04FR. AUK, involving alternating fragments of subtype A, K, and unclassified (U) fragments, representing a new CRF called CRF45_AKU. Some of the unclassified fragments were related to unclassified regions described in either CRF04 or CRF09 strains. Careful reanalysis of HIV-1 MAL and HIV-1 NOGIL3 demonstrated that these strains were related exclusively to CRF45_AKU and either two subtype D fragments for HIV-1 MAL or one subtype H segment for HIV-1 NOGIL3. Following extensive blast searches, related gag, pol, and env sequences were observed in Central and West Africa (Senegal, Mali), as well as in Europe (France, Spain, Italy, Cyprus), Argentina, and China. specialized CAMEROUN GABON REPUBLIQUE DEMOCRATIQUE DU CONGO 052 25 12 1345-1353 2009 0889-2229 https://www.documentation.ird.fr/hor/fdi:010048445 10.1089/aid.2009.0169 0889-2229 [F B010048445] https://www.documentation.ird.fr/hor/fdi:010048445 https://www.documentation.ird.fr/intranet/publi/2010/01/010048445.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-02-08 2017-08-23 fdi:010048445 fre