Buffet P. A., Briand Valérie, Renia L., Thellier M., Danis M., Mazier D. (2008). Intermittent preventive antimalarial treatment to children (IPTc) : firebreak or fire trap ?. Trends in Parasitology, 24 (11), p. 482-485. ISSN 1471-4922.
Titre du document
Intermittent preventive antimalarial treatment to children (IPTc) : firebreak or fire trap ?
Buffet P. A., Briand Valérie, Renia L., Thellier M., Danis M., Mazier D.
Source
Trends in Parasitology, 2008,
24 (11), p. 482-485 ISSN 1471-4922
Intermittent preventive treatment is the prescheduled administration of antimalarial drugs to at-risk patients in endemic areas. This approach, which is recommended for pregnant women, is being evaluated in children. Sulfadoxine-pyrimethamine plus amodiaquine recently proved to be more protective than artemisinin-containing regimens. Therefore, the use of artemisinin derivatives could potentially be restricted to symptomatic patients. Determinants of three pending issues: safety, efficacy throughout childhood, and effectiveness - the latter depending on the implementation of sustainable delivery mechanisms - are analyzed in this comment.
