%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Buffet, P. A.
%A Briand, Valérie
%A Renia, L.
%A Thellier, M.
%A Danis, M.
%A Mazier, D.
%T Intermittent preventive antimalarial treatment to children (IPTc) : firebreak or fire trap ?
%D 2008
%L fdi:010044150
%G ENG
%J Trends in Parasitology
%@ 1471-4922
%M ISI:000261159900002
%N 11
%P 482-485
%R 10.1016/j.pt.2008.07.007
%U https://www.documentation.ird.fr/hor/fdi:010044150
%> https://www.documentation.ird.fr/intranet/publi/2008/12/010044150.pdf
%V 24
%W Horizon (IRD)
%X Intermittent preventive treatment is the prescheduled administration of antimalarial drugs to at-risk patients in endemic areas. This approach, which is recommended for pregnant women, is being evaluated in children. Sulfadoxine-pyrimethamine plus amodiaquine recently proved to be more protective than artemisinin-containing regimens. Therefore, the use of artemisinin derivatives could potentially be restricted to symptomatic patients. Determinants of three pending issues: safety, efficacy throughout childhood, and effectiveness - the latter depending on the implementation of sustainable delivery mechanisms - are analyzed in this comment.
%$ 052