Djogbénou Luc, Dabiré R., Diabaté A., Kengne Pierre, Akogbéto M., Hougard Jean-Marc, Chandre Fabrice. (2008). Identification and geographic distribution of the ACE-1(R) mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa. American Journal of Tropical Medicine and Hygiene, 78 (2), p. 298-302. ISSN 0002-9637.
Titre du document
Identification and geographic distribution of the ACE-1(R) mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa
Djogbénou Luc, Dabiré R., Diabaté A., Kengne Pierre, Akogbéto M., Hougard Jean-Marc, Chandre Fabrice
Source
American Journal of Tropical Medicine and Hygiene, 2008,
78 (2), p. 298-302 ISSN 0002-9637
Resistance of Anopheles gambiae to organophosphate and carbamate insecticides was first reported in Cote d'Ivoire, West Africa. Subsequent studies revealed that it resulted from a single point mutation in the oxyanion hole of the acetycholinesterase enzyme (ace-1(R) mutation). We investigated the distribution and prevalence of the ace-1(R) mutation in An. gambiae s.l. populations from seven locations in south-western Burkina Faso. The ace-1(R) mutation was found in both M and S molecular forms of An. gambiae s.s., but it was absent in An. arabiensis. Its frequency ranged from 0.25 to 0.5 in S form and 0.04 to 0.13 in M form, though they were sympatric. The lack of homozygous resistance indicated a strong genetic cost associated with the mutation. These data suggest that organophosphate and carbamate resistance conferred by target site insensitivity is spreading in populations of An. gambiae s.s. from West Africa.
