@article{fdi:010042492,
  title = {{I}dentification and geographic distribution of the {ACE}-1({R}) mutation in the malaria vector {A}nopheles gambiae in south-western {B}urkina {F}aso, {W}est {A}frica},
  author = {{D}jogb{\'e}nou, {L}uc and {D}abir{\'e}, {R}. and {D}iabat{\'e}, {A}. and {K}engne, {P}ierre and {A}kogb{\'e}to, {M}. and {H}ougard, {J}ean-{M}arc and {C}handre, {F}abrice},
  editor = {},
  language = {{ENG}},
  abstract = {{R}esistance of {A}nopheles gambiae to organophosphate and carbamate insecticides was first reported in {C}ote d'{I}voire, {W}est {A}frica. {S}ubsequent studies revealed that it resulted from a single point mutation in the oxyanion hole of the acetycholinesterase enzyme (ace-1({R}) mutation). {W}e investigated the distribution and prevalence of the ace-1({R}) mutation in {A}n. gambiae s.l. populations from seven locations in south-western {B}urkina {F}aso. {T}he ace-1({R}) mutation was found in both {M} and {S} molecular forms of {A}n. gambiae s.s., but it was absent in {A}n. arabiensis. {I}ts frequency ranged from 0.25 to 0.5 in {S} form and 0.04 to 0.13 in {M} form, though they were sympatric. {T}he lack of homozygous resistance indicated a strong genetic cost associated with the mutation. {T}hese data suggest that organophosphate and carbamate resistance conferred by target site insensitivity is spreading in populations of {A}n. gambiae s.s. from {W}est {A}frica.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {78},
  numero = {2},
  pages = {298--302},
  ISSN = {0002-9637},
  year = {2008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042492},
}