Diabate A., Baldet Thierry, Chandre Fabrice, Dabire K.R., Kengne Pierre, Guiguembe T.R., Simard Frédéric, Guillet Pierre, Hemingway J., Hougard Jean-Marc. (2003). KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West Africa. Journal of Medical Entomology, 40 (2), p. 195-198. ISSN 0022-2585.
Titre du document
KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West Africa
Année de publication
2003
Auteurs
Diabate A., Baldet Thierry, Chandre Fabrice, Dabire K.R., Kengne Pierre, Guiguembe T.R., Simard Frédéric, Guillet Pierre, Hemingway J., Hougard Jean-Marc
Source
Journal of Medical Entomology, 2003,
40 (2), p. 195-198 ISSN 0022-2585
A sodium channel 'kdr'-type mutation was identified in the M form of Anopheles gambiae from Burkina Faso in the tropical savannah area belt. The molecular M form of An. gambiae is found at high frequencies in the flooded rice cultivation area of Kou Valley, where the insecticide selection pressure is limited. The spread of the mutation in the M population is an ongoing process, as it increased from a frequency of 0.006 in 1999 to 0.02 in 2000. The S molecular form occurs in sympatry in our study village, with the M form at a relatively low frequency. The common 'kdr' mutation was previously detected in this area in the S form, and has probably invaded the M population through genetic introgression. This impacts on the question of actual levels of gene flow between the two molecular forms in tropical savannah areas. A hybrid M/S individual was identified during the course of this study, which was homozygous for the 'kdr' mutation. Pyrethroid resistant An. gambiae were caught in October and November, which is the time of year that the molecular S form migrates into this area as rain-fed breeding sites in the cotton fields dry out.
Plan de classement
Lutte [052ANOPAL04]
Descripteurs
PALUDISME ; VECTEUR ; MOUSTIQUE ; MUTATION ; INSECTICIDE CHIMIQUE ; SENSIBILITE RESISTANCE ; ANALYSE GENETIQUE ; VARIATION SAISONNIERE ; SAVANE ; PERMETHRINE ; MUTATION KDR
Description Géographique
ZONE TROPICALE ; BURKINA FASO
Localisation
Fonds IRD [F B010030651] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010030651
