KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West Africa

KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West Africa Diabate A. auteur aut IRD Baldet Thierry auteur aut IRD Chandre Fabrice auteur aut IRD Dabire K.R. auteur aut IRD Kengne Pierre auteur aut IRD Guiguembe T.R. auteur aut IRD Simard Frédéric auteur aut IRD Guillet Pierre auteur aut IRD Hemingway J. auteur aut IRD Hougard Jean-Marc auteur aut IRD text journalArticle eng text/pdf born digital access A sodium channel 'kdr'-type mutation was identified in the M form of Anopheles gambiae from Burkina Faso in the tropical savannah area belt. The molecular M form of An. gambiae is found at high frequencies in the flooded rice cultivation area of Kou Valley, where the insecticide selection pressure is limited. The spread of the mutation in the M population is an ongoing process, as it increased from a frequency of 0.006 in 1999 to 0.02 in 2000. The S molecular form occurs in sympatry in our study village, with the M form at a relatively low frequency. The common 'kdr' mutation was previously detected in this area in the S form, and has probably invaded the M population through genetic introgression. This impacts on the question of actual levels of gene flow between the two molecular forms in tropical savannah areas. A hybrid M/S individual was identified during the course of this study, which was homozygous for the 'kdr' mutation. Pyrethroid resistant An. gambiae were caught in October and November, which is the time of year that the molecular S form migrates into this area as rain-fed breeding sites in the cotton fields dry out. specialized PALUDISME VECTEUR MOUSTIQUE MUTATION INSECTICIDE CHIMIQUE SENSIBILITE RESISTANCE ANALYSE GENETIQUE VARIATION SAISONNIERE SAVANE PERMETHRINE MUTATION KDR ZONE TROPICALE BURKINA FASO 052ANOPAL04 Journal of Medical Entomology 40 2 195-198 2003 0022-2585 https://www.documentation.ird.fr/hor/fdi:010030651 10.1603/0022-2585-40.2.195 0022-2585 [F B010030651] https://www.documentation.ird.fr/hor/fdi:010030651 https://www.documentation.ird.fr/intranet/publi/depot/2010-06-23/010030651.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2003-05-22 2020-10-15 fdi:010030651 fre