Peeters Martine, Esu-Williams E., Vergne Laurence, Montavon Céline, Mulanga Kabeya Claire, Harry T., Ibironke A., Lesage D., Patrel Delphine, Delaporte Eric. (2000). Predominance of subtype A and G HIV type 1 in Nigeria, with geographical differences in their distribution. AIDS Research and Human Retroviruses, 16 (4), p. 315-325. ISSN 0889-2229.
Titre du document
Predominance of subtype A and G HIV type 1 in Nigeria, with geographical differences in their distribution
Année de publication
2000
Auteurs
Peeters Martine, Esu-Williams E., Vergne Laurence, Montavon Céline, Mulanga Kabeya Claire, Harry T., Ibironke A., Lesage D., Patrel Delphine, Delaporte Eric
Source
AIDS Research and Human Retroviruses, 2000,
16 (4), p. 315-325 ISSN 0889-2229
The purpose of this study was to generate data on the relative prevalences of the HIV-1 subtypes circulating in Nigeria. A total of 252 HIV-1 positive samples collected during an epidemiologic survey conducted in April 1996 were genetically characterized by HMA (heteroduplex mobility assay) and/or sequencing. Samples were collected in Lagos, Calabar, Kano, and Maiduguri. Overall, the predominant env subtypes were A (61.3%) and G (37.5%). Subtype A is more prevalent in the south (p is less than 0.001), about 70% in Lagos and Calabar, whereas a quarter of the samples was classified as subtype G in these states. In contrast, subtype G is predominant in the north (p is less than 0.001), representing 58% of the samples in Kano. In the northeastern region, Maiduguri, almost similar proportions of subtype A and G were seen, 49 and 47.4%, respectively. A total of 37 samples was also sequenced in the p24 region from the gag gene ; 13 (35%) had discordant subtype designations between env and gag. The majority of the gag (12 of 17) and env (14 of 22) subtype A sequences clustered with the A/G-IBNG strain. Whithin subtype G, three different subclusters were seen among the envelope sequences. These different subclusters are observed among samples obtained from asymptomatic individuals and AIDS patients from the four Nigerian states studied. In conclusion, we observed a limited number of HIV-1 subtypes circulating in Nigeria, with subtypes A and G being the major env subtypes responsible for the HIV-1 epidemic. Nevertheless, the high rate of recombinant viruses (A/G) and the different A/G recombinant structures indicate a complex pattern of HIV-1 viruses circulating in this country. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; VIRUS ; PREVALENCE ; ANALYSE GENETIQUE ; DIVERSITE GENETIQUE ; IDENTIFICATION ; TECHNIQUE PCR ; REPARTITION GEOGRAPHIQUE
Description Géographique
NIGERIA ; KANO
Localisation
Fonds IRD [F B010024050] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010024050
