Farokhi F., Wielgosz-Collin G., Robic A., Debitus Cécile, Malleter M., Roussakis C., Kornprobst J. M., Barnathan G. (2012). Antiproliferative activity against human non-small cell lung cancer of two O-alkyl-diglycosylglycerols from the marine sponges Myrmekioderrna dendyi and Trikentrion laeve. European Journal of Medicinal Chemistry, 49, p. 406-410. ISSN 0223-5234.
Titre du document
Antiproliferative activity against human non-small cell lung cancer of two O-alkyl-diglycosylglycerols from the marine sponges Myrmekioderrna dendyi and Trikentrion laeve
Farokhi F., Wielgosz-Collin G., Robic A., Debitus Cécile, Malleter M., Roussakis C., Kornprobst J. M., Barnathan G.
Source
European Journal of Medicinal Chemistry, 2012,
49, p. 406-410 ISSN 0223-5234
Glycolipids of Myrmekioderma sponges contain Myrmekiosides, a new family of glycolipids with a unique structure of mono-O-alkyl-diglycosylglycerols. This report deals with the identification and biological activity of the new Myrmekioside E from Myrmekioderma dendyi. Its structure has been elucidated from spectroscopic data and chemical degradation studies. It contained a glycerol backbone linked to xylose and N-acetylglucosamine, and an alkyl long-chain with a terminal alcohol group. A related glycolipid, Trikentroside, known in the sponge Trikentrion laeve, was subjected to a comparative biological evaluation. Both glycolipids inhibit proliferation of two human non-small cell lung cancer cell lines (NSCLC-N6 and A549).
