%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Farokhi, F.
%A Wielgosz-Collin, G.
%A Robic, A.
%A Debitus, Cécile
%A Malleter, M.
%A Roussakis, C.
%A Kornprobst, J. M.
%A Barnathan, G.
%T Antiproliferative activity against human non-small cell lung cancer of two O-alkyl-diglycosylglycerols from the marine sponges Myrmekioderrna dendyi and Trikentrion laeve
%D 2012
%L PAR00008873
%G ENG
%J European Journal of Medicinal Chemistry
%@ 0223-5234
%K Alkyldiglycosylglycerols ; Glycolipids ; Human lung cancer ; Marine sponges ; Myrmekioderma ; Trikentrion
%M ISI:000302033300039
%P 406-410
%R 10.1016/j.ejmech.2012.01.029
%U https://www.documentation.ird.fr/hor/PAR00008873
%> https://www.documentation.ird.fr/intranet/publi/2012/05/010055779.pdf
%V 49
%W Horizon (IRD)
%X Glycolipids of Myrmekioderma sponges contain Myrmekiosides, a new family of glycolipids with a unique structure of mono-O-alkyl-diglycosylglycerols. This report deals with the identification and biological activity of the new Myrmekioside E from Myrmekioderma dendyi. Its structure has been elucidated from spectroscopic data and chemical degradation studies. It contained a glycerol backbone linked to xylose and N-acetylglucosamine, and an alkyl long-chain with a terminal alcohol group. A related glycolipid, Trikentroside, known in the sponge Trikentrion laeve, was subjected to a comparative biological evaluation. Both glycolipids inhibit proliferation of two human non-small cell lung cancer cell lines (NSCLC-N6 and A549).
%$ 035 ; 050