Afoulous S., Ferhout H., Raoelison E. G., Valentin A., Moukarzel Béatrice, Couderc F., Bouajila J. (2011). Helichrysum gymnocephalum essential oil : chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations. Molecules, 16 (10), p. 8273-8291. ISSN 1420-3049.
Titre du document
Helichrysum gymnocephalum essential oil : chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations
Année de publication
2011
Auteurs
Afoulous S., Ferhout H., Raoelison E. G., Valentin A., Moukarzel Béatrice, Couderc F., Bouajila J.
Source
Molecules, 2011,
16 (10), p. 8273-8291 ISSN 1420-3049
Helichrysum gymnocephalum essential oil (EO) was prepared by hydrodistillation of its leaves and characterized by GC-MS and quantified by GC-FID. Twenty three compounds were identified. 1,8-Cineole (47.4%), bicyclosesquiphellandrene (5.6%), gamma-curcumene (5.6%), alpha-amorphene (5.1%) and bicyclogermacrene (5%) were the main components. Our results confirmed the important chemical variability of H. gymnocephalum. The essential oil was tested in vitro for cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum: FcB1-Columbia strain, chloroquine-resistant) and antioxidant (ABTS and DPPH assays) activities. H. gymnocephalum EO was found to be active against MCF-7 cells, with an IC50 of 16 +/- 2 mg/L. The essential oil was active against P. falciparum (IC50 = 25 +/- 1 mg/L). However, the essential oil exhibited a poor antioxidant activity in the DPPH (IC50 value > 1,000 mg/L) and ABTS (IC50 value = 1,487.67 +/- 47.70 mg/L) assays. We have reviewed the existing results on the anticancer activity of essential oils on MCF-7 cell line and on their antiplasmodial activity against the P. falciparum. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial and anticancer). beta-Selinene (R-2 = 0.76), alpha-terpinolene (R-2 = 0.88) and aromadendrene (R-2 = 0.90) presented a higher relationship with the anti-cancer activity. However, only calamenene (R-2 = 0.70) showed a significant correlation for the antiplasmodial activity.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010054180]
Identifiant IRD
PAR00008283
