%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Afoulous, S.
%A Ferhout, H.
%A Raoelison, E. G.
%A Valentin, A.
%A Moukarzel, Béatrice
%A Couderc, F.
%A Bouajila, J.
%T Helichrysum gymnocephalum essential oil : chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations
%D 2011
%L PAR00008283
%G ENG
%J Molecules
%@ 1420-3049
%K Helichrysum gymnocephalum ; GC-MS ; antimalarial activity ; cytotoxic ; activity ; antioxidant activity
%M ISI:000296973000010
%N 10
%P 8273-8291
%R 10.3390/molecules16108273
%U https://www.documentation.ird.fr/hor/PAR00008283
%> https://www.documentation.ird.fr/intranet/publi/2011/12/010054180.pdf
%V 16
%W Horizon (IRD)
%X Helichrysum gymnocephalum essential oil (EO) was prepared by hydrodistillation of its leaves and characterized by GC-MS and quantified by GC-FID. Twenty three compounds were identified. 1,8-Cineole (47.4%), bicyclosesquiphellandrene (5.6%), gamma-curcumene (5.6%), alpha-amorphene (5.1%) and bicyclogermacrene (5%) were the main components. Our results confirmed the important chemical variability of H. gymnocephalum. The essential oil was tested in vitro for cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum: FcB1-Columbia strain, chloroquine-resistant) and antioxidant (ABTS and DPPH assays) activities. H. gymnocephalum EO was found to be active against MCF-7 cells, with an IC50 of 16 +/- 2 mg/L. The essential oil was active against P. falciparum (IC50 = 25 +/- 1 mg/L). However, the essential oil exhibited a poor antioxidant activity in the DPPH (IC50 value > 1,000 mg/L) and ABTS (IC50 value = 1,487.67 +/- 47.70 mg/L) assays. We have reviewed the existing results on the anticancer activity of essential oils on MCF-7 cell line and on their antiplasmodial activity against the P. falciparum. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial and anticancer). beta-Selinene (R-2 = 0.76), alpha-terpinolene (R-2 = 0.88) and aromadendrene (R-2 = 0.90) presented a higher relationship with the anti-cancer activity. However, only calamenene (R-2 = 0.70) showed a significant correlation for the antiplasmodial activity.
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