Roca Y., Baronti Cécile, Revollo R. J., Cook S., Loayza R., Ninove L., Fernandez R. T., Flores J.V., Hervé Jean-Pierre, Lamballerie Xavier de. (2009). Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008. Vector-Borne and Zoonotic Diseases, 9 (3), p. 337-344. ISSN 1530-3667.
Titre du document
Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008
Année de publication
2009
Auteurs
Roca Y., Baronti Cécile, Revollo R. J., Cook S., Loayza R., Ninove L., Fernandez R. T., Flores J.V., Hervé Jean-Pierre, Lamballerie Xavier de
Source
Vector-Borne and Zoonotic Diseases, 2009,
9 (3), p. 337-344 ISSN 1530-3667
Dengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied. We determined that, during the last decade, closely related viruses circulated during several consecutive years (5, 6, and 6 years for DENV-1, DENV-2, and DENV-3, respectively) and the co-circulation of two or even three serotypes was observed. Emergence of new variants (distinct from those identified during the previous episodes) was identified in the case of DENV-1 (2007 outbreak) and DENV-2 (2001 outbreak). In all cases, it is likely that the viruses originated from neighboring countries.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Identifiant IRD
PAR00003858
