Roca Y. auteur aut IRD Baronti Cécile auteur aut IRD Revollo R. J. auteur aut IRD Cook S. auteur aut IRD Loayza R. auteur aut IRD Ninove L. auteur aut IRD Fernandez R. T. auteur aut IRD Flores J.V. auteur aut IRD Hervé Jean-Pierre auteur aut IRD Lamballerie Xavier de auteur aut IRD text journalArticle eng Dengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied. We determined that, during the last decade, closely related viruses circulated during several consecutive years (5, 6, and 6 years for DENV-1, DENV-2, and DENV-3, respectively) and the co-circulation of two or even three serotypes was observed. Emergence of new variants (distinct from those identified during the previous episodes) was identified in the case of DENV-1 (2007 outbreak) and DENV-2 (2001 outbreak). In all cases, it is likely that the viruses originated from neighboring countries. specialized Dengue Epidemiology Genetics 052 9 3 337-344 2009 1530-3667 https://www.documentation.ird.fr/hor/PAR00003858 10.1089/vbz.2008.0187 1530-3667 https://www.documentation.ird.fr/hor/PAR00003858 IRD - Base Horizon / Pleins textes 2009-07-24 2017-08-23 PAR00003858 fre