Marsal Anouk. (2023). Évaluation de la pertinence du potentiel oxydant en tant que métrique sanitaire pour l'exposition à la pollution atmosphérique.
Grenoble : Université Grenoble Alpes, 238 p. multigr. Th : Sci. de la Terre et de l'Environnement, Université Grenoble Alpes. 2023/11/08.
Titre du document
Évaluation de la pertinence du potentiel oxydant en tant que métrique sanitaire pour l'exposition à la pollution atmosphérique
Année de publication
2023
Type de document
Diplôme
Auteurs
Marsal Anouk
Source
Grenoble : Université Grenoble Alpes, 2023,
238 p. multigr.
Diplôme
Th : Sci. de la Terre et de l'Environnement, Université Grenoble Alpes. 2023/11/08.
Epidemiological studies suggest that the majority of chronic effects of air pollution arise from atmospheric particles (PM), although it is challenging to precisely isolate the effect of each pollutant due to their correlation. A key parameter determining the toxicity of PM is their ability to induce the production of reactive oxygen species (ROS), which can disrupt the redox balance of the lungs and create oxidative stress. Both acellular and cellular methods have been developed to quantify the ability of PM to generate ROS in vivo: this new metric is defined as the oxidative potential (OP) of PM. The OP incorporates the size and surface properties of particles as well as their chemical composition, providing a unique measure that may be indicative of their interactions with specific targets within the human body. This thesis work will facilitate significant advancements in validating the oxidative potential of PM as a relevant indicator of the impact of particle exposure on health, with the following objectives:1) Estimate the population's exposure to aerosol oxidative potential in a medium-sized city and characterize its spatiotemporal variability.2) Characterize the associations between OP measurements and objective health measures within a volunteer cohort. These associations will be compared to those obtained for the current regulatory metric (mass concentration of particles).
