@phdthesis{fdi:010092420,
  title = {Évaluation de la pertinence du potentiel oxydant en tant que m{\'e}trique sanitaire pour l'exposition {\`a} la pollution atmosph{\'e}rique},
  author = {{M}arsal, {A}nouk},
  editor = {},
  language = {{ENG}},
  abstract = {{E}pidemiological studies suggest that the majority of chronic effects of air pollution arise from atmospheric particles ({PM}), although it is challenging to precisely isolate the effect of each pollutant due to their correlation. {A} key parameter determining the toxicity of {PM} is their ability to induce the production of reactive oxygen species ({ROS}), which can disrupt the redox balance of the lungs and create oxidative stress. {B}oth acellular and cellular methods have been developed to quantify the ability of {PM} to generate {ROS} in vivo: this new metric is defined as the oxidative potential ({OP}) of {PM}. {T}he {OP} incorporates the size and surface properties of particles as well as their chemical composition, providing a unique measure that may be indicative of their interactions with specific targets within the human body. {T}his thesis work will facilitate significant advancements in validating the oxidative potential of {PM} as a relevant indicator of the impact of particle exposure on health, with the following objectives:1) {E}stimate the population's exposure to aerosol oxidative potential in a medium-sized city and characterize its spatiotemporal variability.2) {C}haracterize the associations between {OP} measurements and objective health measures within a volunteer cohort. {T}hese associations will be compared to those obtained for the current regulatory metric (mass concentration of particles).},
  keywords = {{FRANCE}},
  address = {{G}renoble},
  publisher = {{U}niversit{\'e} {G}renoble {A}lpes},
  pages = {238  multigr.},
  year = {2023},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092420},
}