Influence of microbiota on clinical expressions of respiratory viral infections

2024

Article référencé dans le Web of Science WOS:001205762100035

Diouf F. S., Alou M. T., Million M., Diatta Georges, Goumballa N., Ndiaye D., Bassene H., Dubourg G., Raoult D., Sokhna Cheikh, Lagier J. C.

American Journal of Tropical Medicine and Hygiene, 2024, 110 (2), p. 391-398 ISSN 0002-9637

Respiratory infections, mainly due to viruses, are among the leading causes of worldwide morbidity andmortality. We investigated the prevalence of viruses and bacteria in a cross-sectional survey conducted in Dielmo, a vil-lage in rural Senegal with a population of 481 inhabitants. Nasopharyngeal sampling was performed in 50 symptomaticsubjects and 101 asymptomatic subjects. Symptomatic subjects were defined as individuals presenting with clinicalsigns of respiratory infection, whereas asymptomatic subjects were recruited in the same households. The identificationof pathogens was performed by polymerase chain reaction for 18 respiratory viruses and eight respiratory bacteria.The prevalence results for respiratory viruses detected in each study group demonstrated that 83.6% of symptomatic samples were positive for at least one respiratory virus, and 21.8% were detected in asymptomatic samples. Influenza A(P50.0001), metapneumovirus (P50.04), and enterovirus (P50.001) were significantly more prevalent in symptomatic patients. Overall, 82.0% of symptomatic subjects and 26.9% of asymptomatic subjects were positive for at least onerespiratory bacterium. The most frequent pathogenic bacteria detected were Moraxella catarrhalis (56%) and Streptococcus pneumoniae (48.0%) among symptomatic individuals, whereas in asymptomatic subjects Corynebacterium propin-quumwas more prevalent (18%). A principal component analysis showed that parainfluenzas 2 and 4 were associated with asymptomatic subjects, whereas influenza A was associated with the presence of symptoms. Considering theseresults, a large epidemiological surveillance of the circulation of these respiratory pathogens in the general populationshould be conducted to provide a better understanding of their carriage and to potentially prevent epidemics

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Biotechnologies [084]

SENEGAL

Fonds IRD [F B010090632]

fdi:010090632