Sorng S., Balayssac S., Danoun S., Assemat G., Mirre A., Cristofoli V., Le Lamer A. C., Jullian Valérie, Gilard V., Fabre N., Martino R., Malet-Martino M. (2022). Quality assessment of Curcuma dietary supplements : complementary data from LC-MS and H-1 NMR. Journal of Pharmaceutical and Biomedical Analysis, 212, p. 114631 [22 p.]. ISSN 0731-7085.
Titre du document
Quality assessment of Curcuma dietary supplements : complementary data from LC-MS and H-1 NMR
Année de publication
2022
Auteurs
Sorng S., Balayssac S., Danoun S., Assemat G., Mirre A., Cristofoli V., Le Lamer A. C., Jullian Valérie, Gilard V., Fabre N., Martino R., Malet-Martino M.
Source
Journal of Pharmaceutical and Biomedical Analysis, 2022,
212, p. 114631 [22 p.] ISSN 0731-7085
Due to the numerous potential health benefits of Curcuma, turmeric dietary supplements (DS) are among the top selling products. To assess the quality of these formulations, thirty Curcuma DS along with five standard Curcuma rhizomes were analyzed with UHPLC-MS and H-1 NMR. The chemometric treatment of the UHPLC-MS spectra showed a significant variability of their chemical composition that was confirmed by H-1 NMR which allowed the absolute quantification of the Curcuma major bioactive components, i.e. curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin), and turmerones (aryl-, alpha- and beta-) as well as piperine, a commonly associated curcumin bioavailability enhancer: respectively 3.5-556, 0-8.6, 0.18-8.1 mg/capsule or tablet. The comparison of the actual and claimed quantities of curcuminoids and piperine showed that 58% of the DS contained the expected amounts of actives.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Nutrition, alimentation [054]
Localisation
Fonds IRD [F B010088139]
Identifiant IRD
fdi:010088139
