Mahalingam G., Samtani S., Lam B. P., Lipnicki D. M., Lima-Costa M. F., Blay S. L., Castro-Costa E., Xiao S. F., Guerchet Maëlenn, Preux P. M., Gbessemehlan A., Skoog I., Najar J., Sterner T. R., Scarmeas N., Yannakoulia M., Dardiotis T., Kim K. W., Riedel-Heller S., Rohr S., Pabst A., Shahar S., Numbers K., Ganguli M., Hughes T. F., Chang C. C. H., Crowe M., Ng T. P., Gwee X., Chua D. Q. L., Rymaszewska J., Wolf-Ostermann K., Welmer A. K., Stafford J., Melis R., Vernooij-Dassen M., Jeon Y. H., Sachdev P. S., Brodaty H. (2023). Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing. Alzheimers and Dementia, 19 (11), 5114-5128. ISSN 1552-5260.
Titre du document
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
Année de publication
2023
Auteurs
Mahalingam G., Samtani S., Lam B. P., Lipnicki D. M., Lima-Costa M. F., Blay S. L., Castro-Costa E., Xiao S. F., Guerchet Maëlenn, Preux P. M., Gbessemehlan A., Skoog I., Najar J., Sterner T. R., Scarmeas N., Yannakoulia M., Dardiotis T., Kim K. W., Riedel-Heller S., Rohr S., Pabst A., Shahar S., Numbers K., Ganguli M., Hughes T. F., Chang C. C. H., Crowe M., Ng T. P., Gwee X., Chua D. Q. L., Rymaszewska J., Wolf-Ostermann K., Welmer A. K., Stafford J., Melis R., Vernooij-Dassen M., Jeon Y. H., Sachdev P. S., Brodaty H.
Source
Alzheimers and Dementia, 2023,
19 (11), 5114-5128 ISSN 1552-5260
Introduction Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers. Methods We used individual participant data (N = 39271, M-age = 70.67 (40-102), 58.86% female, M-education = 8.43 years, Mfollow-up = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes. ResultsWe found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. Discussion Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. Highlights Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI.Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia.Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality.Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
Plan de classement
Santé : généralités [050]
Description Géographique
MONDE
Localisation
Fonds IRD [F B010088086]
Identifiant IRD
fdi:010088086
