@article{fdi:010088086,
  title = {{S}ocial connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing},
  author = {{M}ahalingam, {G}. and {S}amtani, {S}. and {L}am, {B}. {P}. and {L}ipnicki, {D}. {M}. and {L}ima-{C}osta, {M}. {F}. and {B}lay, {S}. {L}. and {C}astro-{C}osta, {E}. and {X}iao, {S}. {F}. and {G}uerchet, {M}a{\¨e}lenn and {P}reux, {P}. {M}. and {G}bessemehlan, {A}. and {S}koog, {I}. and {N}ajar, {J}. and {S}terner, {T}. {R}. and {S}carmeas, {N}. and {Y}annakoulia, {M}. and {D}ardiotis, {T}. and {K}im, {K}. {W}. and {R}iedel-{H}eller, {S}. and {R}ohr, {S}. and {P}abst, {A}. and {S}hahar, {S}. and {N}umbers, {K}. and {G}anguli, {M}. and {H}ughes, {T}. {F}. and {C}hang, {C}. {C}. {H}. and {C}rowe, {M}. and {N}g, {T}. {P}. and {G}wee, {X}. and {C}hua, {D}. {Q}. {L}. and {R}ymaszewska, {J}. and {W}olf-{O}stermann, {K}. and {W}elmer, {A}. {K}. and {S}tafford, {J}. and {M}elis, {R}. and {V}ernooij-{D}assen, {M}. and {J}eon, {Y}. {H}. and {S}achdev, {P}. {S}. and {B}rodaty, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {P}revious meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. {H}owever, these used aggregate data from {N}orth {A}merica and {E}urope and examined a limited number of social connection markers. {M}ethods {W}e used individual participant data ({N} = 39271, {M}-age = 70.67 (40-102), 58.86% female, {M}-education = 8.43 years, {M}follow-up = 3.22 years) from 13 longitudinal ageing studies. {A} two-stage meta-analysis of {C}ox regression models examined the association between social connection markers with our primary outcomes. {R}esults{W}e found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment ({MCI}); between social structure and function and lower risk of incident dementia and mortality. {O}nly in {A}sian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. {D}iscussion {D}ifferent aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. {H}ighlights {S}ocial connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident {MCI}.{S}ocial connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia.{S}ocial connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality.{E}vidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident {MCI}, incident dementia, and mortality. {O}nly in {A}sian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.},
  keywords = {dementia ; longitudinal ; meta-analysis ; mild cognitive impairment ; mortality ; social connections ; {MONDE}},
  booktitle = {},
  journal = {{A}lzheimers and {D}ementia},
  volume = {19},
  numero = {11},
  pages = {5114--5128},
  ISSN = {1552-5260},
  year = {2023},
  DOI = {10.1002/alz.13072},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088086},
}