Association of endothelial protein C receptor (EPCR) rs867186 gene polymorphism with increased levels of soluble EPCR and high risk of severe malaria and fatality in Beninese children

2022

Article référencé dans le Web of Science WOS:000898289100001

Blankson S. O., Dikroh L., Tettey P., Tornyigah B., Adamou R., Moussiliou A., Alao M. J., Amoussou A., Padounou C., Milet Jacqueline, Mensah B. A., Aniweh Y., Tuikue Ndam Nicaise, Roussilhon C., Tahar Rachida

Journal of Infectious Diseases, 2022, [Early access], p. [4 p.] ISSN 0022-1899

The endothelial protein C receptor (EPCR)-rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study, quantitative enzyme-linked immunosorbent assay and sequencing were used to assess sEPCR levels and EPCR-rs867186 polymorphism in blood samples from Beninese children with different clinical presentations of malaria. Our findings show that sEPCR levels were higher at hospital admission than during convalescence and that EPCR-rs867186 G allele was associated with increased sEPCR plasma levels, malaria severity, and mortality rate (P < .001, P = .03, and P = .04, respectively), suggesting a role of sEPCR in the pathogenesis of severe malaria. Soluble and endothelial membrane-bound endothelial protein C receptor (EPCR) were found to be involved in cerebral malaria. An A-to-G substitution at the EPCR-rs867186 locus is strongly associated with increased plasma-soluble EPCR levels, malaria severity, and mortality rate.

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]

BENIN

Fonds IRD [F B010086720]

fdi:010086720