Bonnamy M., Galzi Agnès, Gorgues L., Chalvon V., Hébrard Eugénie, Chéron Sophie, Nguyen T.H., Poulicard Nils, Sabot François, Pidon H., Champion Antony, Césari S., Kroj T., Albar Laurence. (2023). Rapid evolution of an RNA virus to escape recognition by a rice nucleotide-binding and leucine-rich repeat domain immune receptor. New Phytologist, 237 (3), 900-913. ISSN 0028-646X.
Titre du document
Rapid evolution of an RNA virus to escape recognition by a rice nucleotide-binding and leucine-rich repeat domain immune receptor
Année de publication
2023
Auteurs
Bonnamy M., Galzi Agnès, Gorgues L., Chalvon V., Hébrard Eugénie, Chéron Sophie, Nguyen T.H., Poulicard Nils, Sabot François, Pidon H., Champion Antony, Césari S., Kroj T., Albar Laurence
Source
New Phytologist, 2023,
237 (3), 900-913 ISSN 0028-646X
Viral diseases are a major limitation for crop production and their control is crucial for sustainable food supply. We investigated by a combination of functional genetics and experimental evolution the resistance of rice to the rice yellow mottle virus which is among the most devastating rice pathogens in Africa and the mechanisms underlying the extremely fast adaptation of the virus to its host. We found that the RYMV3 gene that protects rice against the virus codes for a nucleotide-binding and leucine-rich repeat domain protein (NLRs) from the Mla-like clade of NLRs. RYMV3 detects the virus by forming a recognition complex with the viral coat protein (CP). The virus escapes efficiently from detection by mutations in its CP some of which interfere with the formation of the recognition complex.This study establishes that NLRs confer also in monocotyledonous plants immunity to viruses and reveals an unexpected functional diversity for NLRs of the Mla clade that were only known as fungal disease resistance proteins. In additions, it provides precise insight into the mechanisms by which viruses adapt to plant immunity and gives important knowledge for the development of sustainable resistance against viral diseases of cereals.
Plan de classement
Amélioration des plantes, ressources génétiques [076AMEPLA]
Localisation
Fonds IRD [F B010086596]
Identifiant IRD
fdi:010086596
