Tapela K., Oyawoye F. O., Olwal C. O., Opurum P. C., Amponsah J. A., Segbedzi K. A. L., Tetteh B., Kumi-Ansah F., Mutungi J. K., Obodai E., Amoako E., Agyemang S., Tuikue Ndam Nicaise, Ampofo W. K., Rayner J. C., Awandare G. A., Paemka L., Bediako Y., Quashie P. K. (2022). Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa. BMC Medicine, 20 (1), p. 370 [14 p.]. ISSN 1741-7015.
Titre du document
Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa
Année de publication
2022
Auteurs
Tapela K., Oyawoye F. O., Olwal C. O., Opurum P. C., Amponsah J. A., Segbedzi K. A. L., Tetteh B., Kumi-Ansah F., Mutungi J. K., Obodai E., Amoako E., Agyemang S., Tuikue Ndam Nicaise, Ampofo W. K., Rayner J. C., Awandare G. A., Paemka L., Bediako Y., Quashie P. K.
Source
BMC Medicine, 2022,
20 (1), p. 370 [14 p.] ISSN 1741-7015
Background West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. Methods Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and asymptomatic cases. Cytokine profiling and antibody quantification were performed using Luminex (TM) multiplex assay whereas antigen-driven agglutination assay was used to assess the ABO blood groups. Immune profile levels between symptomatic and asymptomatic groups were compared using the two-tailed Mann-Whitney U test. Multiple comparisons of cytokine levels among and between days were tested using Kruskal-Wallis with Dunn's post hoc test. Correlations within ABO blood grouping (O's and non-O's) and between cytokines were determined using Spearman correlations. Logistic regression analysis was performed to assess the association of various cytokines with asymptomatic phenotype. Results There was a trend linking blood group O to reduced disease severity, but this association was not statistically significant. Generally, symptomatic patients displayed significantly (p < 0.05) higher cytokine levels compared to asymptomatic cases with exception of Eotaxin, which was positively associated with asymptomatic cases. There were also significant (p < 0.05) associations between other immune markers (IL-6, IL-8 and IL-1Ra) and disease severity. Cytokines' clustering patterns differ between symptomatic and asymptomatic cases. We observed a steady decrease in the concentration of most cytokines over time, while anti-SARS-CoV-2 antibody levels were stable for at least a month, regardless of the COVID-19 status. Conclusions The findings suggest that genetic background and pre-existing immune response patterns may in part shape the nature of the symptomatic response against COVID-19 in a West African population. This study offers clear directions to be explored further in larger studies.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
GHANA
Localisation
Fonds IRD [F B010086304]
Identifiant IRD
fdi:010086304
