%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Tapela, K.
%A Oyawoye, F. O.
%A Olwal, C. O.
%A Opurum, P. C.
%A Amponsah, J. A.
%A Segbedzi, K. A. L.
%A Tetteh, B.
%A Kumi-Ansah, F.
%A Mutungi, J. K.
%A Obodai, E.
%A Amoako, E.
%A Agyemang, S.
%A Tuikue Ndam, Nicaise
%A Ampofo, W. K.
%A Rayner, J. C.
%A Awandare, G. A.
%A Paemka, L.
%A Bediako, Y.
%A Quashie, P. K.
%T Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa
%D 2022
%L fdi:010086304
%G ENG
%J BMC Medicine
%@ 1741-7015
%K COVID-19 ; West Africa ; Asymptomatic ; ABO blood groups ; Eotaxin ; Antibodies
%K GHANA
%M ISI:000862718100003
%N 1
%P 370 [14 ]
%R 10.1186/s12916-022-02571-2
%U https://www.documentation.ird.fr/hor/fdi:010086304
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-11/010086304.pdf
%V 20
%W Horizon (IRD)
%X Background West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. Methods Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and asymptomatic cases. Cytokine profiling and antibody quantification were performed using Luminex (TM) multiplex assay whereas antigen-driven agglutination assay was used to assess the ABO blood groups. Immune profile levels between symptomatic and asymptomatic groups were compared using the two-tailed Mann-Whitney U test. Multiple comparisons of cytokine levels among and between days were tested using Kruskal-Wallis with Dunn's post hoc test. Correlations within ABO blood grouping (O's and non-O's) and between cytokines were determined using Spearman correlations. Logistic regression analysis was performed to assess the association of various cytokines with asymptomatic phenotype. Results There was a trend linking blood group O to reduced disease severity, but this association was not statistically significant. Generally, symptomatic patients displayed significantly (p < 0.05) higher cytokine levels compared to asymptomatic cases with exception of Eotaxin, which was positively associated with asymptomatic cases. There were also significant (p < 0.05) associations between other immune markers (IL-6, IL-8 and IL-1Ra) and disease severity. Cytokines' clustering patterns differ between symptomatic and asymptomatic cases. We observed a steady decrease in the concentration of most cytokines over time, while anti-SARS-CoV-2 antibody levels were stable for at least a month, regardless of the COVID-19 status. Conclusions The findings suggest that genetic background and pre-existing immune response patterns may in part shape the nature of the symptomatic response against COVID-19 in a West African population. This study offers clear directions to be explored further in larger studies.
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