Publications des scientifiques de l'IRD

Suurbaar J., Moussiliou A., Tahar Rachida, Olsen R. W., Adams Y., Dalgaard N., Baafour E. K., Adukpo S., Hviid L., Kusi K. A., Alao J., Ofori M. F., Tuikue Ndam Nicaise, Jensen A. R. (2022). ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children. Scientific Reports - Nature, 12 (1), p. 12994 [12 p.]. ISSN 2045-2322.

Titre du document
ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children
Année de publication
2022
Type de document
Article référencé dans le Web of Science WOS:000833335700002
Auteurs
Suurbaar J., Moussiliou A., Tahar Rachida, Olsen R. W., Adams Y., Dalgaard N., Baafour E. K., Adukpo S., Hviid L., Kusi K. A., Alao J., Ofori M. F., Tuikue Ndam Nicaise, Jensen A. R.
Source
Scientific Reports - Nature, 2022, 12 (1), p. 12994 [12 p.] ISSN 2045-2322
Members of the highly polymorphic Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on the surface of infected erythrocytes (IEs) are important virulence factors, which mediate vascular adhesion of IEs via endothelial host receptors and are targets of naturally acquired immunity. The PfEMP1 family can be divided into clinically relevant subgroups, of which some bind intercellular adhesion molecule 1 (ICAM-1). While the acquisition of IgG specific for ICAM-1-binding DBL beta domains is known to differ between PfEMP1 groups, its ability to induce antibody-dependent cellular phagocytosis (ADCP) is unclear. We therefore measured plasma levels of DBL beta-specific IgG, the ability of such IgG to inhibit PfEMP1-binding to ICAM-1, and its ability to opsonize IEs for ADCP, using plasma from Beninese children with severe (SM) or uncomplicated malaria (UM). IgG specific for DBL beta from group A and B ICAM-1-binding PfEMP1 were dominated by IgG1 and IgG3, and were similar in SM and UM. However, levels of plasma IgG inhibiting ICAM-1-binding of group A DBL beta of PFD1235w was significantly higher in children with UM than SM, and acute UM plasma induced a higher ADCP response than acute SM plasma.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010085994]
Identifiant IRD
fdi:010085994
Contact