@article{fdi:010085994,
  title = {{ICAM}-1-binding {P}lasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis {I}g{G} responses in {B}eninese children},
  author = {{S}uurbaar, {J}. and {M}oussiliou, {A}. and {T}ahar, {R}achida and {O}lsen, {R}. {W}. and {A}dams, {Y}. and {D}algaard, {N}. and {B}aafour, {E}. {K}. and {A}dukpo, {S}. and {H}viid, {L}. and {K}usi, {K}. {A}. and {A}lao, {J}. and {O}fori, {M}. {F}. and {T}uikue {N}dam, {N}icaise and {J}ensen, {A}. {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}embers of the highly polymorphic {P}lasmodium falciparum erythrocyte membrane protein 1 ({P}f{EMP}1) family expressed on the surface of infected erythrocytes ({IE}s) are important virulence factors, which mediate vascular adhesion of {IE}s via endothelial host receptors and are targets of naturally acquired immunity. {T}he {P}f{EMP}1 family can be divided into clinically relevant subgroups, of which some bind intercellular adhesion molecule 1 ({ICAM}-1). {W}hile the acquisition of {I}g{G} specific for {ICAM}-1-binding {DBL} beta domains is known to differ between {P}f{EMP}1 groups, its ability to induce antibody-dependent cellular phagocytosis ({ADCP}) is unclear. {W}e therefore measured plasma levels of {DBL} beta-specific {I}g{G}, the ability of such {I}g{G} to inhibit {P}f{EMP}1-binding to {ICAM}-1, and its ability to opsonize {IE}s for {ADCP}, using plasma from {B}eninese children with severe ({SM}) or uncomplicated malaria ({UM}). {I}g{G} specific for {DBL} beta from group {A} and {B} {ICAM}-1-binding {P}f{EMP}1 were dominated by {I}g{G}1 and {I}g{G}3, and were similar in {SM} and {UM}. {H}owever, levels of plasma {I}g{G} inhibiting {ICAM}-1-binding of group {A} {DBL} beta of {PFD}1235w was significantly higher in children with {UM} than {SM}, and acute {UM} plasma induced a higher {ADCP} response than acute {SM} plasma.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {12},
  numero = {1},
  pages = {12994 [12 p.]},
  ISSN = {2045-2322},
  year = {2022},
  DOI = {10.1038/s41598-022-16305-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085994},
}