Morang'a C. M., Ngoi J. M., Gyamfi J., Amuzu D. S. Y., Nuertey B. D., Soglo P. M., Appiah V., Asante I. A., Owusu-Oduro P., Armoo S., Adu-Gyasi D., Amoako N., Oliver-Commey J., Owusu M., Sylverken A., Fenteng E. D., M'Cormack V. V., Tei-Maya F., Quansah E. B., Ayivor-Djanie R., Amoako E. K., Ogbe I. T., Yemi B. K., Osei-Wusu I., Mettle D. N. A., Saiid S., Tapela K., Dzabeng F., Magnussen V., Quaye J., Opurum P. C., Carr R. A., Ababio P. T., Abass A. K., Akoriyea S. K., Amoako E., Kumi-Ansah F., Boakye O. D., Mibut D. K., Odoom T., Ofori-Boadu L., Allegye-Cudjoe E., Dassah S., Asoala V., Asante K. P., Phillips R. O., Osei-Atweneboana M. Y., Gyapong J. O., Kuma-Aboagye P., Ampofo W. K., Duedu K. O., Tuikue Ndam Nicaise, Bediako Y., Quashie P. K., Amenga-Etego L. N., Awandare G. A. (2022). Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021. Nature Communications, 13 (1), p. 2494 [11 p.].
Titre du document
Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021
Année de publication
2022
Auteurs
Morang'a C. M., Ngoi J. M., Gyamfi J., Amuzu D. S. Y., Nuertey B. D., Soglo P. M., Appiah V., Asante I. A., Owusu-Oduro P., Armoo S., Adu-Gyasi D., Amoako N., Oliver-Commey J., Owusu M., Sylverken A., Fenteng E. D., M'Cormack V. V., Tei-Maya F., Quansah E. B., Ayivor-Djanie R., Amoako E. K., Ogbe I. T., Yemi B. K., Osei-Wusu I., Mettle D. N. A., Saiid S., Tapela K., Dzabeng F., Magnussen V., Quaye J., Opurum P. C., Carr R. A., Ababio P. T., Abass A. K., Akoriyea S. K., Amoako E., Kumi-Ansah F., Boakye O. D., Mibut D. K., Odoom T., Ofori-Boadu L., Allegye-Cudjoe E., Dassah S., Asoala V., Asante K. P., Phillips R. O., Osei-Atweneboana M. Y., Gyapong J. O., Kuma-Aboagye P., Ampofo W. K., Duedu K. O., Tuikue Ndam Nicaise, Bediako Y., Quashie P. K., Amenga-Etego L. N., Awandare G. A.
Source
Nature Communications, 2022,
13 (1), p. 2494 [11 p.]
The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
GHANA
Localisation
Fonds IRD [F B010084776]
Identifiant IRD
fdi:010084776
