Pion Sébastien, Chesnais Cédric, Weil G. J., Louya F., Boussinesq Michel, Missamou F. (2022). Impact of semi-annual albendazole on lymphatic filariasis and soil-transmitted helminth infection : parasitological assessment after 14 rounds of community treatment. American Journal of Tropical Medicine and Hygiene, 106 (2), p. 729-731. ISSN 0002-9637.
Titre du document
Impact of semi-annual albendazole on lymphatic filariasis and soil-transmitted helminth infection : parasitological assessment after 14 rounds of community treatment
Pion Sébastien, Chesnais Cédric, Weil G. J., Louya F., Boussinesq Michel, Missamou F.
Source
American Journal of Tropical Medicine and Hygiene, 2022,
106 (2), p. 729-731 ISSN 0002-9637
Between October 2012 and October 2015, we conducted a community trial to assess the impact of semi-annual (twice yearly) community treatment with albendazole on lymphatic filariasis in Seke Pembe, a village in the Republic of the Congo. Semi-annual community treatment with albendazole has been continued in the community since October 2015. We conducted an additional parasitological assessment survey in October 2019, 6 months after the 14th round of semi-annual treatment. Between October 2012 and October 2015, Wuchereria bancrofti antigenemia and microfilaremia rates in the community had decreased from 17.3% to 4.7% and from 5.3% to 0.3%, respectively. In October 2019, the antigenemia rate had decreased further to 2.8% (19 of 687). No microfilariae were found in night blood smears from persons with circulating filarial antigenemia (0 of 16), suggesting that W. bancrofti transmission has been interrupted in Seke Pembe. Semi-annual albendazole treatments also reduced significantly infection rates with soil transmitted helminths.
