Publications des scientifiques de l'IRD

Diallo M. S. K., Toure A., Sow M. S., Kpamou C., Keita A. K., Taverne Bernard, Peeters Martine, Msellati Philippe, Barry T. A., Etard Jean-François, Ecochard R., Delaporte E., PostEboGui Study Group. (2021). Understanding long-term evolution and predictors of sequelae of Ebola virus disease survivors in Guinea : a 48-month prospective, longitudinal cohort study (PostEboGui). Clinical Infectious Diseases, 73 (12), p. 2166-2174. ISSN 1058-4838.

Titre du document
Understanding long-term evolution and predictors of sequelae of Ebola virus disease survivors in Guinea : a 48-month prospective, longitudinal cohort study (PostEboGui)
Année de publication
2021
Type de document
Article référencé dans le Web of Science WOS:000743384700003
Auteurs
Diallo M. S. K., Toure A., Sow M. S., Kpamou C., Keita A. K., Taverne Bernard, Peeters Martine, Msellati Philippe, Barry T. A., Etard Jean-François, Ecochard R., Delaporte E., PostEboGui Study Group
Source
Clinical Infectious Diseases, 2021, 73 (12), p. 2166-2174 ISSN 1058-4838
Background. Longitudinal analyses are needed to better understand long-term Ebola virus disease (EVD) sequelae. We aimed to estimate the prevalence, incidence, and duration of sequelae and to identify risk factors associated with symptom occurrence among EVD survivors in Guinea. Methods. We followed 802 EVD survivors over 48 months and recorded clinical symptoms with their start/end dates. Prevalence, incidence, and duration of sequelae were calculated. Risk factors associated with symptom occurrence were assessed using an extended Cox model for recurrent events. Results. Overall, the prevalence and incidence of all symptoms decreased significantly over time, but sequelae remained present 48 months after Ebola treatment center discharge with a prevalence of 30.68% (95% confidence interval [CI] 21.40-39.96) for abdominal, 30.55% (95% CI 20.68-40.41) for neurologic, 5.80% (95% CI 1.96-9.65) for musculoskeletal, and 4.24% (95% CI 2.26-6.23) for ocular sequelae. Half of all patients (50.70%; 95% CI 47.26-54.14) complained of general symptoms 2 years' postdischarge and 25.35% (95% CI 23.63-27.07) 4 years' post-discharge. Hemorrhage (hazard ratio [HR], 2.70; P=.007), neurologic (HR 2.63; P=.021), and general symptoms (HR 0.34; P=.003) in the EVD acute phase were significantly associated with the further occurrence of ocular sequelae, whereas hemorrhage (HR 1.91; P=.046) and abdominal (HR 2.21; P=.033) symptoms were significantly associated with musculoskeletal sequelae. Conclusions. Our findings provide new insight into the long-term clinical complications of EVD and their significant association with symptoms in the acute phase, thus reinforcing the importance of regular, long-term follow-up for EVD survivors.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
GUINEE
Localisation
Fonds IRD [F B010084224]
Identifiant IRD
fdi:010084224
Contact