@article{fdi:010084224,
  title = {{U}nderstanding long-term evolution and predictors of sequelae of {E}bola virus disease survivors in {G}uinea : a 48-month prospective, longitudinal cohort study ({P}ost{E}bo{G}ui)},
  author = {{D}iallo, {M}. {S}. {K}. and {T}oure, {A}. and {S}ow, {M}. {S}. and {K}pamou, {C}. and {K}eita, {A}. {K}. and {T}averne, {B}ernard and {P}eeters, {M}artine and {M}sellati, {P}hilippe and {B}arry, {T}. {A}. and {E}tard, {J}ean-{F}ran{\c{c}}ois and {E}cochard, {R}. and {D}elaporte, {E}. and {P}ost{E}bo{G}ui {S}tudy {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {L}ongitudinal analyses are needed to better understand long-term {E}bola virus disease ({EVD}) sequelae. {W}e aimed to estimate the prevalence, incidence, and duration of sequelae and to identify risk factors associated with symptom occurrence among {EVD} survivors in {G}uinea. {M}ethods. {W}e followed 802 {EVD} survivors over 48 months and recorded clinical symptoms with their start/end dates. {P}revalence, incidence, and duration of sequelae were calculated. {R}isk factors associated with symptom occurrence were assessed using an extended {C}ox model for recurrent events. {R}esults. {O}verall, the prevalence and incidence of all symptoms decreased significantly over time, but sequelae remained present 48 months after {E}bola treatment center discharge with a prevalence of 30.68% (95% confidence interval [{CI}] 21.40-39.96) for abdominal, 30.55% (95% {CI} 20.68-40.41) for neurologic, 5.80% (95% {CI} 1.96-9.65) for musculoskeletal, and 4.24% (95% {CI} 2.26-6.23) for ocular sequelae. {H}alf of all patients (50.70%; 95% {CI} 47.26-54.14) complained of general symptoms 2 years' postdischarge and 25.35% (95% {CI} 23.63-27.07) 4 years' post-discharge. {H}emorrhage (hazard ratio [{HR}], 2.70; {P}=.007), neurologic ({HR} 2.63; {P}=.021), and general symptoms ({HR} 0.34; {P}=.003) in the {EVD} acute phase were significantly associated with the further occurrence of ocular sequelae, whereas hemorrhage ({HR} 1.91; {P}=.046) and abdominal ({HR} 2.21; {P}=.033) symptoms were significantly associated with musculoskeletal sequelae. {C}onclusions. {O}ur findings provide new insight into the long-term clinical complications of {EVD} and their significant association with symptoms in the acute phase, thus reinforcing the importance of regular, long-term follow-up for {EVD} survivors.},
  keywords = {{E}bola survivors ; sequelae ; prevalence ; {C}ox models ; recurrent events ; {GUINEE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {73},
  numero = {12},
  pages = {2166--2174},
  ISSN = {1058-4838},
  year = {2021},
  DOI = {10.1093/cid/ciab168},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084224},
}