Dudas G., Hong S. L., Potter B. I., Calvignac-Spencer S., Niatou-Singa F. S., Tombolomako T. B., Fuh-Neba T., Vickos U., Ulrich M., Leendertz F. H., Khan K., Huber C., Watts A., Olendraite I., Snijder J., Wijnant K. N., Bonvin A.M.J.J., Martres P., Behillil S., Ayouba Ahidjo, Maidadi M. F., Djomsi D. M., Godwe C., Butel Christelle, et al. (2021). Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions. Nature Communications, 12 (1), 5769 [12 p.].
Titre du document
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
Année de publication
2021
Auteurs
Dudas G., Hong S. L., Potter B. I., Calvignac-Spencer S., Niatou-Singa F. S., Tombolomako T. B., Fuh-Neba T., Vickos U., Ulrich M., Leendertz F. H., Khan K., Huber C., Watts A., Olendraite I., Snijder J., Wijnant K. N., Bonvin A.M.J.J., Martres P., Behillil S., Ayouba Ahidjo, Maidadi M. F., Djomsi D. M., Godwe C., Butel Christelle, et al.
Source
Nature Communications, 2021,
12 (1), 5769 [12 p.]
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69 Delta, Y144 Delta, and LLA241/243 Delta. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers. Here, the authors describe the emergence and spread of a new potential SARS-CoV-2 variant of interest, B.1.620. They show that this lineage, first identified in Lithuania, has established local transmission in Europe on multiple occasions and likely emerged in Central Africa.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
EUROPE ; AFRIQUE CENTRALE ; CAMEROUN ; CENTRAFRIQUE
Localisation
Fonds IRD [F B010083214]
Identifiant IRD
fdi:010083214
