Dujon A. M., Brown J. S., Destoumieux-Garzon D., Vittecoq M., Hamede R., Tasiemski A., Boutry J., Tissot S., Alix-Panabieres C., Pujol P., Renaud F., Simard Frédéric, Roche Benjamin, Ujvari B., Thomas F. (2021). On the need for integrating cancer into the One Health perspective. Evolutionary Applications, 14 (11), 2571-2575. ISSN 1752-4571.
Titre du document
On the need for integrating cancer into the One Health perspective
Année de publication
2021
Auteurs
Dujon A. M., Brown J. S., Destoumieux-Garzon D., Vittecoq M., Hamede R., Tasiemski A., Boutry J., Tissot S., Alix-Panabieres C., Pujol P., Renaud F., Simard Frédéric, Roche Benjamin, Ujvari B., Thomas F.
Source
Evolutionary Applications, 2021,
14 (11), 2571-2575 ISSN 1752-4571
Recent pandemics have highlighted the urgency to connect disciplines studying animal, human, and environment health, that is, the "One Health" concept. The One Health approach takes a holistic view of health, but it has largely focused on zoonotic diseases while not addressing oncogenic processes. We argue that cancers should be an additional key focus in the One Health approach based on three factors that add to the well-documented impact of humans on the natural environment and its implications on cancer emergence. First, human activities are oncogenic to other animals, exacerbating the dynamics of oncogenesis, causing immunosuppressive disorders in wildlife with effects on host-pathogen interactions, and eventually facilitating pathogen spillovers. Second, the emergence of transmissible cancers in animal species (including humans) has the potential to accelerate biodiversity loss across ecosystems and to become pandemic. It is crucial to understand why, how, and when transmissible cancers emerge and spread. Third, translating knowledge of tumor suppressor mechanisms found across the Animal Kingdom to human health offers novel insights into cancer prevention and treatment strategies.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Sciences du milieu [021]
;
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
Localisation
Fonds IRD [F B010083209]
Identifiant IRD
fdi:010083209
