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Sondo P., Bihoun B., Kabore B., Tahita M. C., Derra K., Rouamba T., Diallo S. N., Kazienga A., Ilboudo H., Valea I., Tarnagda Z., Sorgho H., Lefèvre Thierry, Tinto H. (2021). Polymorphisms in Plasmodium falciparum parasites and mutations in the resistance genes Pfcrt and Pfmdr1 in Nanoro area, Burkina Faso. Pan African Medical Journal, 39, p. 118 [9 p.]. ISSN 1937-8688.

Titre du document
Polymorphisms in Plasmodium falciparum parasites and mutations in the resistance genes Pfcrt and Pfmdr1 in Nanoro area, Burkina Faso
Année de publication
2021
Type de document
Article référencé dans le Web of Science WOS:000687304000001
Auteurs
Sondo P., Bihoun B., Kabore B., Tahita M. C., Derra K., Rouamba T., Diallo S. N., Kazienga A., Ilboudo H., Valea I., Tarnagda Z., Sorgho H., Lefèvre Thierry, Tinto H.
Source
Pan African Medical Journal, 2021, 39, p. 118 [9 p.] ISSN 1937-8688
Introduction: from o genetic point of view P. falciparumis extremely polymorphic. There is a variety of parasite strains infesting individuals living in malaria endemic areas. The purpose of this study is to investigate the relationship between polymorphisms in Plasmodium falciparum parasites and Pfcrt and Pfmdr1 gene mutations in Nanoro area, Burkina Faso. Methods: blood samples from plasmodium carriers residing in the Nanoro Health District were genotyped using nested PCR. Parasite gene mutations associated with resistance to antimalarial drugs were detected by PCR-RFLP. Results: samples of 672 patients were successfully genotyped. No mspland msp2allelic families exhibited an increase in developing mutations in resistance genes. However, mutant strains of these genes were present at greater levels in monoclonal infections than in multi-clonal infections. Conclusion: this study provides an overview of the relationship between polymorphisms in Plasmodium falciparum parasites and mutations in resistance genes. These data will undoubtedly contribute to improving knowledge of the parasite's biology and its mechanisms of resistance to antimalarial drugs.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BURKINA FASO ; NANORO
Localisation
Fonds IRD [F B010082715]
Identifiant IRD
fdi:010082715
 Open Access  DOI  HAL
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