@article{fdi:010082715,
  title = {{P}olymorphisms in {P}lasmodium falciparum parasites and mutations in the resistance genes {P}fcrt and {P}fmdr1 in {N}anoro area, {B}urkina {F}aso},
  author = {{S}ondo, {P}. and {B}ihoun, {B}. and {K}abore, {B}. and {T}ahita, {M}. {C}. and {D}erra, {K}. and {R}ouamba, {T}. and {D}iallo, {S}. {N}. and {K}azienga, {A}. and {I}lboudo, {H}. and {V}alea, {I}. and {T}arnagda, {Z}. and {S}orgho, {H}. and {L}ef{\`e}vre, {T}hierry and {T}into, {H}.},
  editor = {},
  language = {{FRE}},
  abstract = {{I}ntroduction: from o genetic point of view {P}. falciparumis extremely polymorphic. {T}here is a variety of parasite strains infesting individuals living in malaria endemic areas. {T}he purpose of this study is to investigate the relationship between polymorphisms in {P}lasmodium falciparum parasites and {P}fcrt and {P}fmdr1 gene mutations in {N}anoro area, {B}urkina {F}aso. {M}ethods: blood samples from plasmodium carriers residing in the {N}anoro {H}ealth {D}istrict were genotyped using nested {PCR}. {P}arasite gene mutations associated with resistance to antimalarial drugs were detected by {PCR}-{RFLP}. {R}esults: samples of 672 patients were successfully genotyped. {N}o mspland msp2allelic families exhibited an increase in developing mutations in resistance genes. {H}owever, mutant strains of these genes were present at greater levels in monoclonal infections than in multi-clonal infections. {C}onclusion: this study provides an overview of the relationship between polymorphisms in {P}lasmodium falciparum parasites and mutations in resistance genes. {T}hese data will undoubtedly contribute to improving knowledge of the parasite's biology and its mechanisms of resistance to antimalarial drugs.},
  keywords = {{P}lasmodium falciparum ; msp1 ; msp2 ; {P}fcrt ; {P}fmdr1 ; {BURKINA} {FASO} ; {NANORO}},
  booktitle = {},
  journal = {{P}an {A}frican {M}edical {J}ournal},
  volume = {39},
  numero = {},
  pages = {118 [9 p.]},
  ISSN = {1937-8688},
  year = {2021},
  DOI = {10.11604/pamj.2021.39.118.26959},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082715},
}