Groussin M., Poyet M., Sistiaga A., Kearney S. M., Moniz K., Noel M., Hooker J., Gibbons S. M., Segurel L., Froment Alain, Mohamed R. S., Fezeu A., Juimo V. A., Lafosse S., Tabe F. E., Girard C., Iqaluk D., Nguyen L. T., Shapiro B. J., Lehtimaki J., Ruokolainen L., Kettunen P. P., Vatanen T., Sigwazi S., Mabulla A., Dominguez-Rodrigo M., Nartey Y. A., Agyei-Nkansah A., Duah A., Awuku Y. A., Valles K. A., Asibey S. O., Afihene M. Y., Roberts L. R., Plymoth A., Onyekwere C. A., Summons R. E., Xavier R. J., Alm E. J. (2021). Elevated rates of horizontal gene transfer in the industrialized human microbiome. Cell, 184 (8), p. 2053-2067 + e1-e18. ISSN 0092-8674.
Titre du document
Elevated rates of horizontal gene transfer in the industrialized human microbiome
Année de publication
2021
Auteurs
Groussin M., Poyet M., Sistiaga A., Kearney S. M., Moniz K., Noel M., Hooker J., Gibbons S. M., Segurel L., Froment Alain, Mohamed R. S., Fezeu A., Juimo V. A., Lafosse S., Tabe F. E., Girard C., Iqaluk D., Nguyen L. T., Shapiro B. J., Lehtimaki J., Ruokolainen L., Kettunen P. P., Vatanen T., Sigwazi S., Mabulla A., Dominguez-Rodrigo M., Nartey Y. A., Agyei-Nkansah A., Duah A., Awuku Y. A., Valles K. A., Asibey S. O., Afihene M. Y., Roberts L. R., Plymoth A., Onyekwere C. A., Summons R. E., Xavier R. J., Alm E. J.
Source
Cell, 2021,
184 (8), p. 2053-2067 + e1-e18 ISSN 0092-8674
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Biotechnologies [084]
Description Géographique
ETATS UNIS ; CANADA ; FINLANDE ; CAMEROUN ; TANZANIE ; GHANA ; NIGERIA
Localisation
Fonds IRD [F B010081478]
Identifiant IRD
fdi:010081478
