@article{fdi:010081478,
  title = {{E}levated rates of horizontal gene transfer in the industrialized human microbiome},
  author = {{G}roussin, {M}. and {P}oyet, {M}. and {S}istiaga, {A}. and {K}earney, {S}. {M}. and {M}oniz, {K}. and {N}oel, {M}. and {H}ooker, {J}. and {G}ibbons, {S}. {M}. and {S}egurel, {L}. and {F}roment, {A}lain and {M}ohamed, {R}. {S}. and {F}ezeu, {A}. and {J}uimo, {V}. {A}. and {L}afosse, {S}. and {T}abe, {F}. {E}. and {G}irard, {C}. and {I}qaluk, {D}. and {N}guyen, {L}. {T}. and {S}hapiro, {B}. {J}. and {L}ehtimaki, {J}. and {R}uokolainen, {L}. and {K}ettunen, {P}. {P}. and {V}atanen, {T}. and {S}igwazi, {S}. and {M}abulla, {A}. and {D}ominguez-{R}odrigo, {M}. and {N}artey, {Y}. {A}. and {A}gyei-{N}kansah, {A}. and {D}uah, {A}. and {A}wuku, {Y}. {A}. and {V}alles, {K}. {A}. and {A}sibey, {S}. {O}. and {A}fihene, {M}. {Y}. and {R}oberts, {L}. {R}. and {P}lymoth, {A}. and {O}nyekwere, {C}. {A}. and {S}ummons, {R}. {E}. and {X}avier, {R}. {J}. and {A}lm, {E}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ndustrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. {W}hether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. {H}ere, we investigate the extent to which the rates and targets of horizontal gene transfer ({HGT}) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. {W}e show that {HGT}s have accumulated in the microbiome over recent host generations and that {HGT} occurs at high frequency within individuals. {C}omparison across human populations reveals that industrialized lifestyles are associated with higher {HGT} rates and that the functions of {HGT}s are related to the level of host industrialization. {O}ur results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of {HGT} may be a recent development in human history linked to industrialization.},
  keywords = {{ETATS} {UNIS} ; {CANADA} ; {FINLANDE} ; {CAMEROUN} ; {TANZANIE} ; {GHANA} ; {NIGERIA}},
  booktitle = {},
  journal = {{C}ell},
  volume = {184},
  numero = {8},
  pages = {2053--2067 + e1--e18},
  ISSN = {0092-8674},
  year = {2021},
  DOI = {10.1016/j.cell.2021.02.052},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081478},
}