Kinganda-Lusamaki E., Black A., Mukadi D. B., Hadfield J., Mbala-Kingebeni P., Pratt C. B., Aziza A., Diagne M. M., White B., Bisento N., Nsunda B., Akonga M., Faye M., Faye O., Edidi-Atani F., Matondo-Kuamfumu M., Mambu-Mbika F., Bulabula J., Di Paola N., Pauthner M. G., Andersen K. G., Palacios G., Delaporte E., Sall A. A., Peeters Martine, Wiley M. R., Ahuka-Mundeke S., Bedford T., Tamfum J. J. M. (2021). Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo. Nature Medicine, 27 (4), 710-716. ISSN 1078-8956.
Titre du document
Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo
Année de publication
2021
Auteurs
Kinganda-Lusamaki E., Black A., Mukadi D. B., Hadfield J., Mbala-Kingebeni P., Pratt C. B., Aziza A., Diagne M. M., White B., Bisento N., Nsunda B., Akonga M., Faye M., Faye O., Edidi-Atani F., Matondo-Kuamfumu M., Mambu-Mbika F., Bulabula J., Di Paola N., Pauthner M. G., Andersen K. G., Palacios G., Delaporte E., Sall A. A., Peeters Martine, Wiley M. R., Ahuka-Mundeke S., Bedford T., Tamfum J. J. M.
Source
Nature Medicine, 2021,
27 (4), 710-716 ISSN 1078-8956
On 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomedicale (INRB) implemented an end-to-end genomic surveillance system, including sequencing, bioinformatic analysis and dissemination of genomic epidemiologic results to frontline public health workers. We report 744 new genomes sampled between 27 July 2018 and 27 April 2020 generated by this surveillance effort. Together with previously available sequence data (n = 48 genomes), these data represent almost 24% of all laboratory-confirmed Ebola virus (EBOV) infections in DRC in the period analyzed. We inferred spatiotemporal transmission dynamics from the genomic data as new sequences were generated, and disseminated the results to support epidemiologic response efforts. Here we provide an overview of how this genomic surveillance system functioned, present a full phylodynamic analysis of 792 Ebola genomes from the Nord Kivu outbreak and discuss how the genomic surveillance data informed response efforts and public health decision making. Phylogeographic analysis of 792 Ebola virus genomes from the 2018 oubreak in the Democratic Republic of the Congo integrated into an end-to-end surveillance program demonstrates the feasibility of using genomic sequencing data to inform the public health epidemic response in near-real time.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
KIVU NORD
Localisation
Fonds IRD [F B010081313]
Identifiant IRD
fdi:010081313
