@article{fdi:010081313,
  title = {{I}ntegration of genomic sequencing into the response to the {E}bola virus outbreak in {N}ord {K}ivu, {D}emocratic {R}epublic of the {C}ongo},
  author = {{K}inganda-{L}usamaki, {E}. and {B}lack, {A}. and {M}ukadi, {D}. {B}. and {H}adfield, {J}. and {M}bala-{K}ingebeni, {P}. and {P}ratt, {C}. {B}. and {A}ziza, {A}. and {D}iagne, {M}. {M}. and {W}hite, {B}. and {B}isento, {N}. and {N}sunda, {B}. and {A}konga, {M}. and {F}aye, {M}. and {F}aye, {O}. and {E}didi-{A}tani, {F}. and {M}atondo-{K}uamfumu, {M}. and {M}ambu-{M}bika, {F}. and {B}ulabula, {J}. and {D}i {P}aola, {N}. and {P}authner, {M}. {G}. and {A}ndersen, {K}. {G}. and {P}alacios, {G}. and {D}elaporte, {E}. and {S}all, {A}. {A}. and {P}eeters, {M}artine and {W}iley, {M}. {R}. and {A}huka-{M}undeke, {S}. and {B}edford, {T}. and {T}amfum, {J}. {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}n 1 {A}ugust 2018, the {D}emocratic {R}epublic of the {C}ongo ({DRC}) declared its tenth {E}bola virus disease ({EVD}) outbreak. {T}o aid the epidemiologic response, the {I}nstitut {N}ational de {R}echerche {B}iomedicale ({INRB}) implemented an end-to-end genomic surveillance system, including sequencing, bioinformatic analysis and dissemination of genomic epidemiologic results to frontline public health workers. {W}e report 744 new genomes sampled between 27 {J}uly 2018 and 27 {A}pril 2020 generated by this surveillance effort. {T}ogether with previously available sequence data (n = 48 genomes), these data represent almost 24% of all laboratory-confirmed {E}bola virus ({EBOV}) infections in {DRC} in the period analyzed. {W}e inferred spatiotemporal transmission dynamics from the genomic data as new sequences were generated, and disseminated the results to support epidemiologic response efforts. {H}ere we provide an overview of how this genomic surveillance system functioned, present a full phylodynamic analysis of 792 {E}bola genomes from the {N}ord {K}ivu outbreak and discuss how the genomic surveillance data informed response efforts and public health decision making. {P}hylogeographic analysis of 792 {E}bola virus genomes from the 2018 oubreak in the {D}emocratic {R}epublic of the {C}ongo integrated into an end-to-end surveillance program demonstrates the feasibility of using genomic sequencing data to inform the public health epidemic response in near-real time.},
  keywords = {{KIVU} {NORD} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{N}ature {M}edicine},
  volume = {27},
  numero = {4},
  pages = {710--716},
  ISSN = {1078-8956},
  year = {2021},
  DOI = {10.1038/s41591-021-01302-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081313},
}